Healthcare Professionals

2022 Meta-analysis

A 2022 meta-analysis by Wijesuriya et al. consolidated findings from five pivotal studies conducted between 2014 and 2021. These studies collectively analyzed the outcomes of 175 HF patients who underwent the WiSE CRT System implantation. Key findings include:

Improved echocardiographic response:

Average improvement in LVEF of 6.3% between baseline and 6-month follow-up across all 5 studies.

Improved NYHA classification:

Mean reduction of New York Heart Association (NYHA) class of 4.3 points.

Improved clinical response:

The pooled clinical response rate was 68% between baseline and 6-month follow-up.

High implant and procedural success:

Implant success rate was 96.6% with four studies reporting biventricular capture at six months in 90.6% of patients.

Limitations:

Non-randomized patients, small number of studies, heterogeneity of inclusions criteria, and a short follow-up duration of six months.

Conclusions and future directions:

Efficacy of leadless left ventricular endocardial pacing with the WiSE CRT System was shown, supporting its use as a second-line therapy in patients in whom standard CRT has failed or is not possible.